The immune-inflammatory response of oligodendrocytes in a murine model of preterm white matter injury: the role of TLR3 activation
Marta Boccazzi, Juliette Van Steenwinckel, Anne-Laure Schang, Valérie Faivre, Tifenn Le Charpentier, Cindy Bokobza, Zsolt Csaba, Claudia Verderio, Marta Fumagalli, Shyamala Mani and Pierre Gressens
Cell Death Dis 12, 166 (2021); https://doi.org/10.1038/s41419-021-03446-9
Received: 2 June 2020 / Revised: 13 December 2020 / Accepted: 3 January 2021 / Available online: 8 February 2021
This study focused on toll-like receptor-3, a protein activated by double-strand RNA, which promotes neuroinflammation. The aim was to better understand its expression and role in oligodendrocytes (one of the last types of cell to form in the brain). The in vivo mouse model mimicked white matter injury occurring in preterm babies.
Therapeutic potential of stem cells for preterm infant brain damage: can we move from the heterogeneity of preclinical and clinical studies to established therapeutics?
Sofia Passera, Marta Boccazzi, Cindy Bokobza, Valerie Faivre, Fabio Mosca, Juliette Van Steenwinckel, Monica Fumagalli, Pierre Gressens and Bobbi Fleiss
Biochemical Pharmacology 2021, 114461; https://doi.org/10.3390/biom11010099
Received: 10 December 2020 / Revised: 27 January 2021 / Accepted: 2 February 2021 / Available online: 8 February 2021
In this review, the researchers summarise and discuss preclinical and clinical investigations which have studied stem cells as an effective neuroprotectant for perinatal brain injury.
Microglia-Mediated Neurodegeneration in Perinatal Brain Injuries
Bobbi Fleiss, Juliette Van Steenwinckel, Cindy Bokobza, Isabelle K. Shearer, Emily Ross-Munro and Pierre Gressens
Biomolecules 2021, 11(1), 99; https://doi.org/10.3390/biom11010099
Received: 29 November 2020 / Revised: 8 January 2021 / Accepted: 11 January 2021 / Published: 13 January 2021
This review looks at strategies developed experimentally to modulate microglia and reduce brain injury in babies. It focusses on four causes of perinatal brain injury which occur frequently in both westernised and emerging countries, including EoP and neonatal stroke, and reviews pharmacological approaches as well as novel nanoparticle mediated therapies.
Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key
Daan R.M.G. Ophelders, Ruth Gussenhoven, Luise Klein, Reint K. Jellema, Rob J.J. Westerlaken, Matthias C. Hütten, Jeroen Vermeulen, Guido Wassink, Alistair J. Gunn and Tim G.A.M. Wolfs
Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders
Bobbi Fleiss, Pierre Gressens and Helen B. Stolp